Last update March 22, 2018

Cocaine

Very High Risk

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding.

High excretion into breast milk which is very toxic for the infant.

Newborn and very young infants eliminate it at a lower rate than adults. Cocaine is detected in urine of infants until 60 hours after a breast feed.

Reportedly, cases of irritability, tremulousness, vomiting, diarrhea, dilated pupils, tachycardia and arterial hypertension in infants whose mothers had taken this drug have occurred.

Applying on mother's nipple as anesthetic is highly hazardous since seizures, lethargy or coma may occur,

Also, severe health troubles by passive inhalation of Cocaine smoke (Crack) have been shown.

Drug abuse behavior incapacitates the mother for appropriate baby care and poses a life hazard for both the mother and the infant.

Bed-sharing is not recommended for mothers who are taking this drug.

After exceptional cocaine consumption a free period of 24 hours should be observed before resuming breastfeeding.

Alternatives

We do not have alternatives for Cocaine.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cocaine is also known as


Cocaine in other languages or writings:

Groups

Cocaine belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 303 daltons
Protein Binding 91 %
VD 1,6 - 2,7 l/Kg
Tmax 0,25 hours
T1/2 0,8 hours
Theoretical Dose 0,002 - 0,06 mg/Kg/d

References

  1. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  2. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  3. Vallersnes OM, Dines AM, Wood DM, Yates C, Heyerdahl F, Hovda KE, Giraudon I; Euro-DEN Research Group., Dargan PI. Psychosis associated with acute recreational drug toxicity: a European case series. BMC Psychiatry. 2016 Aug 18;16:293. Abstract Full text (link to original source)
  4. ABM. Reece-Stremtan S, Marinelli KA. ABM Clinical Protocol #21: Guidelines for Breastfeeding and Substance Use or Substance Use Disorder, Revised 2015. Breastfeed Med. 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. ABM Protocolo clínico de la ABM n.º 21: Pautas para la lactancia y el consumo de sustancias o trastorno por consumo de sustancias, revisado en 2015. Breastfeed Med. 2015 Full text (link to original source) Full text (in our servers)
  6. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  7. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  8. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
  9. D'Apolito K. Breastfeeding and substance abuse. Clin Obstet Gynecol. 2013 Mar;56(1):202-11. Abstract
  10. Cressman AM, Koren G, Pupco A, Kim E, Ito S, Bozzo P. Maternal cocaine use during breastfeeding. Can Fam Physician. 2012 Abstract Full text (link to original source) Full text (in our servers)
  11. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  12. Joya X, Fríguls B, Simó M, Civit E, de la Torre R, Palomeque A, Vall O, Pichini S, Garcia-Algar O. Acute heroin intoxication in a baby chronically exposed to cocaine and heroin: a case report. J Med Case Rep. 2011 Abstract Full text (link to original source) Full text (in our servers)
  13. Gerra G, Leonardi C, Cortese E, Zaimovic A, Dell'agnello G, Manfredini M, Somaini L, Petracca F, Caretti V, Raggi MA, Donnini C. Childhood neglect and parental care perception in cocaine addicts: relation with psychiatric symptoms and biological correlates. Neurosci Biobehav Rev. 2009 Abstract
  14. Walsh SL, Stoops WW, Moody DE, Lin SN, Bigelow GE. Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics. Exp Clin Psychopharmacol. 2009 Abstract Full text (link to original source) Full text (in our servers)
  15. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  16. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  17. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  18. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006 Abstract Full text (link to original source) Full text (in our servers)
  19. Sarkar M, Djulus J, Koren G; Motherisk Program, Division of Clinical Parmacology/Toxicology, The Hospital fr Sick Children, University of Toronto,Ontario, Canada. When a cocaine-using mother wishes to breastfeed: proposed guidelines. Ther Drug Monit. 2005 Abstract
  20. Bauer CR, Langer JC, Shankaran S, Bada HS, Lester B, Wright LL, Krause-Steinrauf H, Smeriglio VL, Finnegan LP, Maza PL, Verter J. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med. 2005 Abstract Full text (link to original source) Full text (in our servers)
  21. Winecker RE, Goldberger BA, Tebbett IR, Behnke M, Eyler FD, Karlix JL, Wobie K, Conlon M, Phillips D, Bertholf RL. Detection of cocaine and its metabolites in breast milk. J Forensic Sci. 2001 Abstract
  22. Moretti ME, Lee A, Ito S. Which drugs are contraindicated during breastfeeding? Practice guidelines. Can Fam Physician. 2000 Sep;46:1753-7. Review. Abstract Full text (link to original source) Full text (in our servers)
  23. Bailey DN. Cocaine and cocaethylene binding to human milk. Am J Clin Pathol. 1998 Abstract
  24. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  25. Young SL, Vosper HJ, Phillips SA. Cocaine: its effects on maternal and child health. Pharmacotherapy. 1992 Abstract
  26. Frank DA, Bauchner H, Zuckerman BS, Fried L. Cocaine and marijuana use during pregnancy by women intending and not intending to breast-feed. J Am Diet Assoc. 1992 Abstract
  27. Kharasch SJ, Glotzer D, Vinci R, Weitzman M, Sargent J. Unsuspected cocaine exposure in young children. Am J Dis Child. 1991 Abstract
  28. Heidemann SM, Goetting MG. Passive inhalation of cocaine by infants. Henry Ford Hosp Med J. 1990 Abstract
  29. Bateman DA, Heagarty MC. Passive freebase cocaine ('crack') inhalation by infants and toddlers. Am J Dis Child. 1989 Abstract
  30. Mendelson JH, Mello NK, Teoh SK, Ellingboe J, Cochin J. Cocaine effects on pulsatile secretion of anterior pituitary, gonadal, and adrenal hormones. J Clin Endocrinol Metab. 1989 Abstract
  31. Chaney NE, Franke J, Wadlington WB. Cocaine convulsions in a breast-feeding baby. J Pediatr. 1988 Abstract
  32. Chasnoff IJ, Lewis DE, Squires L. Cocaine intoxication in a breast-fed infant. Pediatrics. 1987 Abstract

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