Last update May 1, 2016


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is excreted into breast milk in clinically non-significant amount. No problems attributable to this drug have been observed among infants whose mothers were receiving this medication.

It may cause an increase of prolactin secretion.

American Academy of Pediatrics states that it is a medication usually compatible with breastfeeding.

Because of the high risk of QT-interval prolongation and cardiac arrhythmias in patients who are taking it, especially if other medicines are associated or patients are affected by other conditions, it has been withdrawn from the market in many countries.


  • Domperidone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cisapride in other languages or writings:


Cisapride belongs to this group or family:


Main tradenames from several countries containing Cisapride in its composition:


Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 484 daltons
Protein Binding 98 %
Tmax 2 hours
T1/2 10 hours
M/P ratio 0.06 -
Theoretical Dose 0.0009 mg/Kg/d
Relative Dose 0.14 %
Ped.Relat.Dose 0.1 - 0.2 %


  1. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  2. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  3. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract
  4. Bennett JR. How safe and acceptable is cisapride? Scand J Gastroenterol Suppl. 1989 Abstract
  5. Hofmeyr GJ, Sonnendecker EW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986 Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM