Last update March 25, 2022

Cisapride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Cisapride, a substituted benzamide, is a prokinetic drug that increases gastrointestinal motility and accelerates gastric emptying. Used in gastroesophageal reflux. Oral administration

It is excreted into breast milk in clinically non-significant amount. (Hofmeyr 1986)

Cisapride may increase prolactin secretion, although less frequently than metoclopramide. (Fumagalli 1994)

American Academy of Pediatrics states that it is a medication usually compatible with breastfeeding. (AAP 2001)

Because of the high risk of QT-interval prolongation and cardiac arrhythmias in patients who are taking it, especially if other medicines are associated or patients are affected by other conditions, it has been withdrawn from the market in many countries. (MedlinePlus 2017, Mahadevan 2006, ONU 2005)


See below the information of this related product:

  • Mosapride Citrate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Domperidone (Safe substance and/or breastfeeding is the best option.)
  • Metoclopramide (Safe substance and/or breastfeeding is the best option.)
  • Omeprazole (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Cisapride is also known as


Cisapride in other languages or writings:

Group

Cisapride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cisapride in its composition:

List of 15 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 484 daltons
Protein Binding 98 %
Tmax 2 hours
T½ 10 hours
M/P ratio 0.06 -
Theoretical Dose 0.0009 mg/Kg/d
Relative Dose 0.14 %
Ped.Relat.Dose 0.1 - 0.2 %

References

  1. MedlinePlus. Cisaprida Información de salud para usted. 2017 Full text (link to original source) Full text (in our servers)
  2. MedlinePlus. Cisapride. Trusted Health information for you. 2017 Full text (link to original source) Full text (in our servers)
  3. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  4. UN- ONU. United Nations Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments. Twelfth issue. None 2005 Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Fumagalli I, Hammer B. Cisapride versus metoclopramide in the treatment of functional dyspepsia. A double-blind comparative trial. Scand J Gastroenterol. 1994 Jan;29(1):33-7. Abstract
  7. Hofmeyr GJ, Sonnendecker EW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986 Abstract

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