Last update June 1, 2024

Chlortetracycline

Compatible

Safe substance and/or breastfeeding is the best option.

Chlortetracycline is a tetracycline derivative with properties similar to those of tetracycline. It is used topically as an ophthalmic ointment and as a skin ointment.  Little used orally due to poor absorption.

At the time of the last update, we found no published data on its excretion in breast milk.

Tetracycline, similar in structure and properties to chlortetracycline, is considered compatible with breast-feeding.

Chlortetracycline is poorly absorbed from the gastrointestinal tract compared to other tetracyclines.

As with most topical dermatological and ophthalmological preparations, the small dosage and low passage into the bloodstream make it compatible with breast-feeding.

Alternatives

  • Tetracycline (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Chlortetracycline in other languages or writings:

Groups

Chlortetracycline belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Chlortetracycline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 - 30 %
Molecular weight 479 daltons
Protein Binding 50 - 55 %
VD 1.4 l/Kg
pKa 2.99 -
Tmax 3 hours
T½ 5.6 hours
M/P ratio 0.4 -

References

  1. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  2. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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