Last update Oct. 15, 2016

Ceftibuten

Compatible

Safe substance and/or breastfeeding is the best option.

Third-generation cephalosporin for oral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Barr 1991).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Ceftibuten since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ceftibuten in other languages or writings:

Group

Ceftibuten belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceftibuten in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 410 daltons
Protein Binding 65 %
VD 0.2 l/Kg
Tmax 2.6 hours
2.4 hours
Theoretical Dose 0 - < 0.15 mg/Kg/d
Relative Dose 0 - < 4 %

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Barr WH, Lin CC, Radwanski E, Lim J, Symchowicz S, Affrime M. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991 Abstract

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