Last update Oct. 15, 2016

Cefazolin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

First-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Fukada 1973, Yoshioka 1979, Zhang 1997).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for Cefazolin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefazolin is also known as


Group

Cefazolin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefazolin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 477 daltons
Protein Binding 89 %
VD 0.14 l/Kg
Tmax 1 - 2 hours
T½ 1 - 2 hours
M/P ratio 0.02 -
Theoretical Dose 0.2 mg/Kg/d
Relative Dose 1.6 %
Ped.Relat.Dose 0.2 - 0.4 %

References

  1. van Wattum JJ, Leferink TM, Wilffert B, Ter Horst PGJ. Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):5-17. Abstract
  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  3. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Zhang Y, Zhang Q, Xu Z. [Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women]. Zhonghua Fu Chan Ke Za Zhi. 1997 Abstract
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  8. Yoshioka H, Cho K, Takimoto M, Maruyama S, Shimizu T. Transfer of cefazolin into human milk. J Pediatr. 1979 Abstract
  9. Fukada M. Studies on chemotherapy during the perinatal period with special reference to such derivatives of cephalosporin C as cefazolin, cephaloridine and cephalothin. Jpn J Antibiot. 1973 Abstract

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