Last update Oct. 29, 2024

Carbinoxamine Maleate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

First generation antihistamine (H1) of the ethanolamine type, with anticholinergic action and sedative effect, used in the treatment of allergic disorders. It is a frequent component of drugs for the symptomatic relief of the common cold (FDA 2013). Oral administration every 12 hours. 

As of the last update, we found no published data on its excretion in breast milk and the scarce pharmacokinetic data available do not allow predicting it. 

Drug with very few bibliographic references. Authorized use from 2 years of age.

Monitor somnolence and adequate feeding of the infant. (Chow 2015)

It has an antiprolactin effect that could inhibit lactation in the first weeks after delivery.

Due to its sedative effect, bed-sharing with the infant is not recommended if this drug is being taken. (UNICEF 2018, 2017, 2017, 2014, 2014, 2013 and 2006, Landa 2012, ABM 2008)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Carbinoxamine Maleate in other languages or writings:

Group

Carbinoxamine Maleate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Carbinoxamine Maleate in its composition:

  • Afebrin™. Contains other elements than Carbinoxamine Maleate in its composition
  • Arbinoxa
  • Benegrip Multi™. Contains other elements than Carbinoxamine Maleate in its composition
  • Carb PSE 12 DM™. Contains other elements than Carbinoxamine Maleate in its composition
  • Carbodec DM™. Contains other elements than Carbinoxamine Maleate in its composition
  • Carbodex DM™. Contains other elements than Carbinoxamine Maleate in its composition
  • Cordron-DM™. Contains other elements than Carbinoxamine Maleate in its composition
  • Coristina Noite™. Contains other elements than Carbinoxamine Maleate in its composition
  • Histex Ct
  • Karbinal
  • Lentostamin™. Contains other elements than Carbinoxamine Maleate in its composition
  • Naldecon™. Contains other elements than Carbinoxamine Maleate in its composition
  • Nasaliv™. Contains other elements than Carbinoxamine Maleate in its composition
  • Neolefrin™. Contains other elements than Carbinoxamine Maleate in its composition
  • Omega 100
  • Omega 100 Expectorante™. Contains other elements than Carbinoxamine Maleate in its composition
  • Palgic
  • Prindex
  • Rhinocap
  • Rhinopront™. Contains other elements than Carbinoxamine Maleate in its composition
  • Rhinopront (Ринопронт)
  • Rinmax
  • Rinoretard
  • Sildec-DM™. Contains other elements than Carbinoxamine Maleate in its composition
  • Tempra XT™. Contains other elements than Carbinoxamine Maleate in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 407 daltons
pKa 8.1 -
Tmax 5.6 - 6.7 hours
17 (10 - 20) hours

References

  1. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  2. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  3. Chow CK, Koren G. Sedating drugs and breastfeeding. Can Fam Physician. 2015 Abstract Full text (link to original source) Full text (in our servers)
  4. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  5. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  6. FDA-Tris. Carbinoxamine Drug Summary. 2013 Full text (in our servers)
  7. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  8. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  9. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  10. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)

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