Last update Jan. 5, 2019

Carbetocin

Compatible

Safe product and/or breastfeeding is the best option.

Carbetocin is a nonpeptide synthetic oxytocin analog with a longer reported effect duration than oxytocin.
Carbetocin is used to prevent uterine atony and excessive postpartum or post cesarean bleeding (Gallos 2018).
The usual administered dose is 100mcg applied in one dose throughout 1 minute intravenously or intramuscularly.
It is recommended to be administered after the baby is born and preferably before the removal of the placenta.

Carbetocin´s pharmacokinetic properties (high molecular weight and very short half life; Sweeney 1990) account for its negligible transfer to human milk (Silcox 1993) and due to its proteic nature it is easily inactivated in the gastrointestinal tract, without absorption (practically no oral biodisponibility), which will makes it difficult or practically null for any carbetocin to get to the infants plasma from ingested mothers milk (Ferring 2018, GP-Pharm 2014).

The American Academy of Pediatrics considers Carbetocin as a Maternal Medication Usually Compatible with Breastfeeding (AAP 2001).

Alternatives

We do not have alternatives for Carbetocin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Carbetocin is also known as


Carbetocin in other languages or writings:

Group

Carbetocin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Carbetocin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≅ 0 %
Molecular weight 988 daltons
VD 11.4 l/Kg
Tmax 0.1 hours
T½ 0.71 hours
M/P ratio 0.026 -
Theoretical Dose 0.0000044 mg/Kg/d
Relative Dose 0.36 %

References

  1. Gallos ID, Williams HM, Price MJ, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks JJ, Widmer M, Tunçalp Ö, Gülmezoglu AM, Hofmeyr GJ, Coomarasamy A. Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis. Cochrane Database Syst Rev. 2018 Abstract
  2. Ferring. Carbetocin (Duratocin). Drug Summary. 2018 Full text (in our servers)
  3. GP-Pharm. Carbetocina. Ficha técnica. 2014 Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Silcox J, Schulz P, Horbay GL, Wassenaar W. Transfer of carbetocin into human breast milk. Obstet Gynecol. 1993 Abstract
  6. Sweeney G, Holbrook AM, Levine M, Yip M, Alfredsson K, Cappi S et al. Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, in nonpregnant women. Current Therapeutic Research - Clinical and Experimental;47(3):528-540 1990 Abstract Full text (in our servers)

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