Last update Nov. 17, 2024

Capreomycin Sulfate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Capreomycin is an aminoglycoside antibiotic used as a second-line drug in the treatment of tuberculosis when there is resistance to other drugs. Intramuscular or intravenous administration.

At the date of the last update we found no published data on its excretion in breast milk.

Its high molecular weight makes its excretion in breast milk unlikely.

Its practically null oral bioavailability (oral absorption less than 1%) prevents passage into the plasma of the infant from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.

No adverse effects have been reported in infants breastfed by mothers treated with capreomycin that can be directly attributed to this drug. (Drobac 2005)

Alternatives

We do not have alternatives for Capreomycin Sulfate.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Capreomycin Sulfate in other languages or writings:

Group

Capreomycin Sulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Capreomycin Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 1 %
Molecular weight 1321 daltons
pKa 10.62 -
Tmax 1.5 hours
5 hours

References

  1. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Sep-Oct;36(5):641-56. Abstract Full text (link to original source) Full text (in our servers)
  2. Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, Shin S. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005 Jun 1;40(11):1689-92. Epub 2005 Apr 18. Abstract Full text (link to original source) Full text (in our servers)

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