Last update Aug. 6, 2021

Calcium Folinate


Safe substance and/or breastfeeding is the best option.

Folinic acid is the active form of folic acid. It is used in the form of its salts: calcium or sodium folinate.
Indicated as an antidote to folic acid antagonists such as methotrexate, trimethoprim or pyrimethamine, together with fluorouracil in the treatment of colorectal cancer and in megaloblastic anemia due to folate deficiency.
Oral, intramuscular or intravenous administration.

At the date of the last update, the authors did not find any published data on its excretion in breast milk.

Since the various salts of folinic acid are active forms of folic acid, which is a physiological nutrient present in the body and in breast milk and more abundant in breastfed infants (Matoth 1965 and 1964, Karin 1957), it is unlikely that they can cause unwanted side effects.

See below the information of this related product:

  • Folic Acid (Safe substance and/or breastfeeding is the best option.)


We do not have alternatives for Calcium Folinate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Calcium Folinate is also known as

Calcium Folinate in other languages or writings:


Main tradenames from several countries containing Calcium Folinate in its composition:


Variable Value Unit
Oral Bioavail. 37 - 97 %
Molecular weight 601 daltons
Protein Binding 35 - 45 %
VD 0.63 - 3.2 l/Kg
pKa 3.47 -
Tmax 2 (oral); 0.5 (IM); 0.2 (IV) hours
3.5 - 6 hours


  1. Pfizer. Folintao cálcico. Ficha técnica. 2019 Full text (in our servers)
  2. BC Cancer. Leucovorin. Drug Summary 2019 Full text (in our servers)
  3. Matoth Y, Pinkas A, Sroka C. Studies on Folic Acid in Infancy: III. Folates in Breast Fed Infants and Their Mothers. Am J Clin Nutr. 1965 Apr;16(4):356-9. Abstract Full text (link to original source)
  4. Matoth Y, Pinkas A, Zamir R, Mooallem F, Grossowicz N. Studies on folic acid in infancy. I. Blood Levels of Folic and Folinic Acid in Healthy Infants. Pediatrics. 1964 Apr;33:507-11. No abstract available. Abstract
  5. KARLIN R. [Research on vitamins in human milk. I. Folinic acid content; variations during lactation]. C R Seances Soc Biol Fil. 1957;151(6):1211-4. French. No abstract available. Abstract

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