Last update Oct. 29, 2024
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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C32 H41 NO2 is Terfenadine in Molecular formula.
Is written in other languages:Main tradenames from several countries containing C32 H41 NO2 in its composition:
Variable | Value | Unit |
---|---|---|
Molecular weight | 472 | daltons |
Protein Binding | 97 | % |
Tmax | 2 - 4 | hours |
T½ | 16 - 23 | hours |
M/P ratio | 0.2 | - |
Theoretical Dose | 0.006 | mg/Kg/d |
Relative Dose | 0.3 - 0.7 | % |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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2nd generation antihistamine, piperidine derivative, with minimal sedative effect. It is entirely metabolized to fexofenadine. Oral administration once a day.
Its high percentage of protein binding explains the minimal observed passage of fexofenadine into milk. (Lucas 1995)
In a telephone follow-up, 10% of infants born to mothers taking terfenadine had colic and irritability, which did not require treatment. (Ito 1993)
American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)
It has been withdrawn from the market in most countries because of the risk of serious cardiac arrhythmias when taken with other drugs and/or grapefruit juice (Benton 1996, Smith 1994, Monahan 1990). Its metabolite, fexofenadine, does not cause arrhythmias.
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