Last update Aug. 30, 2018

C22 H24 N2 O9

Compatible

Safe substance and/or breastfeeding is the best option.

Derived from tetracycline with similar action and indications.
Systemic oral administration (4 times a day) and also intramuscular.
Topical dermatological, gynecological and ophthalmological administration.

It is excreted in breastmilk in insignificant amounts (Gruner 1955, Ottolenghi 1952).
The intestinal absorption by the infant is greatly diminished by the formation of non-absorbable chelates with dairy calcium (Lactmed 2015, Mitrano 2009, Chin 2001).
No problems have been observed in infants whose mothers were taking it (Gruner 1955).

The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to alteration of the intestinal flora (Ito 1993).

The American Academy of Pediatrics considers tetracycline to be usually compatible with breastfeeding (AAP 2001).

The small dose and low plasma absorption of most topical ophthalmological and dermatological preparations make its transfer in significant amounts into breastmilk even more unlikely.

Alternatives

  • Tetracycline (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

C22 H24 N2 O9 is Oxytetracycline in Molecular formula.

Is written in other languages:

C22 H24 N2 O9 is also known as

Groups

C22 H24 N2 O9 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing C22 H24 N2 O9 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 58 %
Molecular weight 460 daltons
Protein Binding 30 (20 - 40) %
VD 1.8 l/Kg
pKa 0.24 -
Tmax 3 hours
T½ 8 - 9 hours
Theoretical Dose 0.04 - 0.15 mg/Kg/d
Relative Dose 0.1 - 0.5 %

References

  1. Acofarma. Oxitetraciclina. Ficha técnica. 2018 Full text (in our servers)
  2. LactMed. Oxytetracycline. Full Record Display. 2015 Full text (in our servers)
  3. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  4. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  5. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  6. Gruner JM. [The excretion of terramycin and tetracycline in human milk]. Geburtshilfe Frauenheld (in: Lactmed 2015). 1955 Abstract
  7. Ottolenghi-Preti GF, Massironi A [Terramycin in lactation; specific method of determination]. Ann Ostet Ginecol (in: LactMed 2015). 1952 Abstract

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