Last update Aug. 31, 2022

C16H15N5O7S2

Compatible

Safe substance and/or breastfeeding is the best option.

This is a third generation Cephalosporin. Oral administration.

At latest update relevant data on excretion into breast milk were not found.

All Cephalosporins for which there is available information are excreted in breast milk in an amount that is therapeutically non-significant. (Rowe 2013)

Cephalosporins are widely used in Pediatrics, even from the neonatal period (Lignieres 201, Hamilton 2020), with very good tolerance, so it is very unlikely that, in small amounts through milk, they can cause problems in infants.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Expert authors consider the use of this medication to be compatible or probably compatible during breastfeeding. (Hale, LactMed, Briggs 2015, Bar-Oz 2003, Fulton 1992)

Alternatives

We do not have alternatives for C16H15N5O7S2 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C16H15N5O7S2 is Cefixime in Molecular formula.

Is written in other languages:

Group

C16H15N5O7S2 belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 - 50 %
Molecular weight 508 daltons
Protein Binding 65 - 70 %
VD 0.1 l/Kg
Tmax 2 - 6 hours
T½ 3 - 4 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Lignieres G, Birgy A, Jung C, Bonacorsi S, Levy C, Angoulvant F, Grimprel E, Dommergues MA, Gillet Y, Craiu I, Rybak A, De Pontual L, Dubos F, Cixous E, Gajdos V, Pinquier D, Andriantahina I, Soussan-Banini V, Georget E, Launay E, Vignaud O, Cohen R, et al. Relay oral therapy in febrile urinary tract infections caused by extended spectrum beta-lactamase-producing Enterobacteriaceae in children: A French multicenter study. PLoS One. 2021 Sep 16;16(9):e0257217. Abstract Full text (link to original source)
  4. Hamilton JL, Evans SG, Bakshi M. Management of Fever in Infants and Young Children. Am Fam Physician. 2020 Jun 15;101(12):721-729. Abstract Full text (link to original source)
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  7. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  8. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  9. Barré J. [Pharmacokinetic properties of cefixime]. Presse Med. 1989 Abstract
  10. Faulkner RD, Fernandez P, Lawrence G, Sia LL, Falkowski AJ, Weiss AI, Yacobi A, Silber BM. Absolute bioavailability of cefixime in man. J Clin Pharmacol. 1988 Abstract
  11. Brittain DC, Scully BE, Hirose T, Neu HC. The pharmacokinetic and bactericidal characteristics of oral cefixime. Clin Pharmacol Ther. 1985 Abstract

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