Last update Feb. 14, 2022

C14H26N4O11P2

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Derivative of choline and cytidine involved in the biosynthesis of lecithin. Unproven properties of increasing cerebral blood flow and improving cognitive performance are attributed to it. It has been used in the treatment of cerebrovascular disorders such as stroke, parkinsonism and others. Intravenous, intramuscular or oral administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

The paucity of known pharmacokinetic data does not allow prediction of its possible excretion in breast milk.

Safe product, free of toxicity, its side effects are rare and mild.

May decrease prolactin production. (Matsuoka 1978)

Its efficacy is not proven (Martí 2020, Dávalos 2012, Clark 1999) and it is considered a drug of low therapeutic utility, perfectly dispensable. (SEFAP 2012, DGF 2011, INSALUD 2001)

Alternatives

We do not have alternatives for C14H26N4O11P2.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C14H26N4O11P2 is Citicoline; Citicoline Sodium in Molecular formula.

Is written in other languages:

C14H26N4O11P2 is also known as

Group

C14H26N4O11P2 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C14H26N4O11P2 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 97 %
Molecular weight 488 daltons
pKa 1.84 -
Tmax 3.3 ± 0.7 hours
66.4 ± 8.5 hours

References

  1. Martí-Carvajal AJ, Valli C, Martí-Amarista CE, Solà I, Martí-Fàbregas J, Bonfill Cosp X. Citicoline for treating people with acute ischemic stroke. Cochrane Database Syst Rev. 2020 Aug 29;8:CD013066. Abstract
  2. SEFAP. Sociedad Española de Farmacéuticos de Atención Primaria. Propuesta de medicamentos a desfinanciar por el Sistema Nacional de Salud. . 2012 Full text (in our servers)
  3. Dávalos A, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Ferro J, Martínez-Vila E, Serena J, Segura T, Cruz VT, Masjuan J, Cobo E, Secades JJ; International Citicoline Trial on acUte Stroke (ICTUS) trial investigators.. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet. 2012 Jul 28;380(9839):349-57. Abstract
  4. DGF. Dirección General de Farmacia. Servicio Canario de la Salud. Listado de fármacos considerados de Utilidad terapéutica Baja (UTB). None 2011 Full text (in our servers)
  5. INSALUD. Área de Gestión de Farmacia. Subdirección General de Atención Primaria. Instituto Nacional de la Salud. Utilidad terapéutica de los medicamentos financiados por el Sistema Nacional de Salud. . 2001 Full text (in our servers)
  6. Clark WM, Williams BJ, Selzer KA, Zweifler RM, Sabounjian LA, Gammans RE. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke. 1999 Dec;30(12):2592-7. Abstract
  7. Matsuoka T, Kawanaka M, Nagai K. Effect of cytidine diphosphate choline on growth hormone and prolactin secretion in man. Endocrinol Jpn. 1978 Feb;25(1):55-7. Abstract

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