Last update June 1, 2017

C14H10O4

Compatible

Safe substance and/or breastfeeding is the best option.

A keratolytic and topical anti-infective agent used in the treatment of acne.

Since the last update we have not found published data on its excretion in breast milk

Only 5% is absorbed through the skin and is quickly eliminated via urine after being metabolized in the skin to benzoic acid (AEMPS 2013, Seubert 1984, Holzmann 1979), so it is not expected to pass into breast milk.
Taken orally, it is destroyed at the gastrointestinal level, so its absorption into milk is zero.

It is considered very low risk during breastfeeding (Kong 2013, Worret 2006, Leachman 2006, Zip 2002).

Do not apply to the chest in order to prevent the infant from ingesting it; if necessary, apply after breastfeeding and clean well with water before the next feed. Applying topical creams, gels and other products which contain paraffin (mineral oil) to the nipple is to be avoided so that the infant does not absorb them. (Concin 2008, Noti 2003).

List of essential medicines WHO: compatible with breastfeeding (WHO / UNICEF 2002).

Alternatives

We do not have alternatives for C14H10O4 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C14H10O4 is Benzoyl Peroxide in Molecular formula.

Is written in other languages:

Group

C14H10O4 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C14H10O4 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Derm: < 5 Oral: 0 %
Molecular weight 242 daltons

References

  1. FDA. U.S. Food & Drug Administration Part 184.1- Substances added directly to human food affirmed as generally recognized as safe (GRAS). CFR. 2023 Consulted on Dec. 12, 2023 Full text (link to original source) Full text (in our servers)
  2. Ly S, Kamal K, Manjaly P, Barbieri JS, Mostaghimi A. Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review. Dermatol Ther (Heidelb). 2023 Jan;13(1):115-130. Abstract Full text (link to original source)
  3. AEMPS. Peróxido de Benzoílo. Ficha técnica. 2013 Full text (in our servers)
  4. Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013 Jun;73(8):779-87. Abstract
  5. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  6. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  7. Worret WI, Fluhr JW. [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. J Dtsch Dermatol Ges. 2006 Abstract
  8. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  9. Zip C. Common sense dermatological drug suggestions for women who are breast-feeding. Skin Therapy Lett. 2002 Abstract
  10. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  11. Seubert S, Seubert A, Ippen H. [Penetration of benzoyl peroxide in the skin]. Hautarzt. 1984 Abstract
  12. Holzmann H, Morsches B, Benes P. The absorption of benzoyl peroxide from leg ulcers. Arzneimittelforschung. 1979 Abstract

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