Last update Jan. 26, 2021

C10H15NO2

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Adrenergic sympathomimetic agent used in the treatment of orthostatic hypotension and cardiovascular syncope.
Oral or intravenous administration.

Since the last update we have not found any published data on its excretion in breast milk.

Its short half-life make transfer into breastmilk in significant quantities unlikely.
Its low oral bioavailability would make it difficult its passage to the infant’s plasma through breast milk except in premature babies and in the immediate neonatal period during which there may be greater intestinal permeability.

Trendelemburg position, may produce the same clinical improvement as (empiric) ethylephrine or propranolol therapy (Di Girolamo 1998).

There are very few bibiographical references and it is marketed in few countries.

Alternatives

We do not have alternatives for C10H15NO2.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C10H15NO2 is Etilefrine Hydrochloride in Molecular formula.

Is written in other languages:

C10H15NO2 is also known as

Group

C10H15NO2 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C10H15NO2 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 12 %
Molecular weight 218 daltons
Protein Binding 23 %
pKa 9.1 -
Tmax 0.33 hours
2 hours

References

  1. Sanofi. Etilefrina. Ficha técnica. 2020 Full text (in our servers)
  2. Sanofi. Etilefrine. Drug Summary. 2005 Full text (in our servers)
  3. Di Girolamo E, Di Iorio C, Sabatini P, Leonzio L, Barsotti A. [Evaluation of the effects of diverse therapeutic treatments versus no treatment of patients with neurocardiogenic syncope]. Cardiologia. 1998 Aug;43(8):833-7. Italian. Abstract

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