Last update Feb. 11, 2025

Butoconazole Nitrate

Compatible

Safe product and/or breastfeeding is the best option.

Butoconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. Topical vaginal administration.

At the date of the last update we found no published data on its excretion in breast milk.

The small dose and negligible systemic absorption through the skin or vaginal mucosa achieve clinically irrelevant plasma levels (Mactal 2001, Fromtling 1988), so that passage into breast milk would be minimal or nil.

Alternatives

  • Clotrimazole (Safe product and/or breastfeeding is the best option.)
  • Miconazole (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Butoconazole Nitrate in other languages or writings:

Group

Butoconazole Nitrate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Butoconazole Nitrate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Vaginal: 5 %
Molecular weight 475 daltons
21 hours

References

  1. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  2. Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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