Last update Dec. 3, 2022


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

A synthetic decapeptide, similar to gonadorelin, analogue of natural luteinizing hormone releasing hormone (LHRH). Indicated in in vitro fertilization treatments before stimulation with exogenous gonadotropins for ovarian stimulation. Subcutaneous administration daily for 15 to 21 days. It is also used in carcinomas of the prostate and endometriosis.

Buserelin, administered by intranasal inhalation, is excreted in human milk in negligible or undetectable amounts and does not cause hormonal alterations in infants breastfed by mothers taking it (Dewart 1987), nor alterations in lactation. (Fraser 1989)

Its high molecular weight would explain this tiny passage into breast milk.

Due to its protein nature, it is inactivated in the gastrointestinal tract (Van Leusden 1994, Fraser 1993), not being absorbed (practically zero oral bioavailability), which hinders its transfer into the infant's plasma from breastmilk, except in premature infants and the immediate neonatal period, when there may be greater intestinal permeability.

Increased prolactin has been observed in women treated with gonadorelin analogues and gonadotropins (Cavagna 2005, Kamel 1994, Meldrum 1992), although the findings are not consistent. (Chantilis 1995)


See below the information of this related product:


We do not have alternatives for Buserelin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Buserelin is also known as

Buserelin in other languages or writings:

  • بوزيريلين (Arabic)
  • Бусерелин (Cyrillic)
  • 布舍瑞林 (Chinese)
  • ブセレリン (Japanese)
  • (6-O-tert-Butyl-d-serine)-des-10-glycinamidegonadorelin ethylamide; 5-Oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-O-tert-butyl-d-seryl-l-leucyl-l-arginyl-N-ethyl-l-prolinamide (Chemical name)
  • C60 H86 N16 O13 (Molecular formula)
  • L02AE01 (ATC Code/s)


Buserelin belongs to this group or family:


Main tradenames from several countries containing Buserelin in its composition:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 1.239 daltons
Protein Binding 15 %
pKa 9.49 -
Tmax 1 hours
1.3 (1 - 2) hours
Theoretical Dose 0.00003 - 0.0013 mg/Kg/d
Relative Dose 0.3 - 13 %


  1. AEMPS- Sanofi Aventis. Buserelina (Suprefact) Ficha técnica. 2016 Full text (in our servers)
  2. Sanofi-Aventis. Buserelin (Suprefact). Drug Summary. 2015 Full text (in our servers)
  3. Cavagna M, Mantese JC, Freitas Gda C, Dzik A, Soares JB, Hameiry Y, Izzo VM, Pinotti JA. Pattern of prolactin secretion after administration of gonadotropin-releasing hormone agonist at the preovulatory phase of intrauterine insemination cycles. Sao Paulo Med J. 2005 Nov 3;123(6):295-7. Epub 2006 Jan 20. Abstract
  4. Chantilis SJ, Barnett-Hamm C, Byrd WE, Carr BR. The effect of gonadotropin-releasing hormone agonist on thyroid-stimulating hormone and prolactin secretion in adult premenopausal women. Fertil Steril. 1995 Oct;64(4):698-702. Abstract
  5. Van Leusden HA. Impact of different GnRH analogs in benign gynecological disorders related to their chemical structure, delivery systems and dose. Gynecol Endocrinol. 1994 Sep;8(3):215-22. Review. Abstract
  6. Kamel MA, Zabel G, Bernart W, Neulen J, Breckwoldt M. Comparison between prolactin, gonadotrophins and steroid hormones in serum and follicular fluid after stimulation with gonadotrophin-releasing hormone agonists and human menopausal gonadotrophin for an in-vitro fertilization programme. Hum Reprod. 1994 Oct;9(10):1803-6. Abstract
  7. Fraser HM. GnRH analogues for contraception. Br Med Bull. 1993 Jan;49(1):62-72. Review. Abstract
  8. Meldrum DR, Cedars MI, Hamilton F, Huynh D, Wisot A, Marr B. Leuprolide acetate elevates prolactin during ovarian stimulation with gonadotropins. J Assist Reprod Genet. 1992 Jun;9(3):251-3. Abstract
  9. Fraser HM, Dewart PJ, Smith SK, Cowen GM, Sandow J, McNeilly AS. Luteinizing hormone releasing hormone agonist for contraception in breast feeding women. J Clin Endocrinol Metab. 1989 Nov;69(5):996-1002. Abstract
  10. Dewart PJ, McNeilly AS, Smith SK, Sandow J, Hillier SG, Fraser HM. LRH agonist buserelin as a post-partum contraceptive: lack of biological activity of buserelin in breast milk. Acta Endocrinol (Copenh). 1987 Feb;114(2):185-92. Abstract

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