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Sympathomimetic alpha-2 adrenergic receptor agonist.
Indicated in the treatment of ocular hypertension, glaucoma and facial erythema of rosacea
Topical administration in the form of eye drops, one drop every 12 hours or as a facial cream, one application every 24 hours.
At the date of the last update, the authors did not find any published data on its excretion in breast milk.
Plasma concentrations are low with ophthalmic treatment and much lower after cutaneous and facial administration (Allergan 2020, EMA 2019 and 2018), which makes the passage to breast milk in significant concentration unlikely.
Although some authors advise against it during lactation due to the possible transition to breast milk (Belkin 2020, Blumen 2020, Salim 2014, Coleman 2005), the truth is that at least two infants of mothers treated with brimonidine (one of them, for 6 months) did not present any clinical problems (Madadi 2008, Johnson 2001).
Systemic absorption should be minimized by pressing the tear duct (inner corner of the eye) with the finger for 1 to 5 minutes and administering the dose immediately after breastfeeding (Belkin 2020, Méndez 2012).