Last update Jan. 18, 2023

Bumetanide

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a loop diuretic with actions and uses similar to those of furosemide. It is used in the treatment of edema associated with heart failure, kidney and liver disorders, and in . hypertension. Oral administration once or twice a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its high protein-binding capacity and short acting (short half-life) make excretion into breast milk in significant amount unlikely. 

Long-term treatment with diuretic drugs may compromise the state of hydration of the nursing mother. Must make an adjustment (decrease) of the dose based on the estimated milk production and monitor milk production. Use a lower dose as possible, especially during the first postnatal month.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Kearney 2018), especially during the neonatal period and in the event of prematurity.

Alternatives

  • Chlorothiazide (Safe product and/or breastfeeding is the best option.)
  • Furosemide (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Hydrochlorothiazide (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Bumetanide in other languages or writings:

Group

Bumetanide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Bumetanide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 - 90 %
Molecular weight 364 daltons
Protein Binding 95 %
VD 0.13 - 0. 36 l/Kg
pKa 4.69 -
Tmax 1 hours
1 - 1.5 hours

References

  1. AEMPS. Bumetanida. Ficha técnica. 2020 Full text (in our servers)
  2. Leo. Bumetanide. Drug Summary. 2018 Full text (in our servers)
  3. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)

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