Last update Oct. 29, 2024

Brompheniramine Maleate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

1st generation antihistamine, alkylamine derivative, with moderate sedative and antimuscarinic effects. Oral administration every 4 to 6 hours.

At the date of the last update we did not find published data on its excretion in breast milk.

Irritability, crying and insomnia have been described in an infant after the mother took a preparation that associated brompheniramine and isoephedrine, possibly responsible for the symptoms. (Mortimer 1977)

Monitor drowsiness and adequate feeding of the infant. 

It has an antiprolactin effect that could inhibit lactation in the first weeks after delivery. 

Due to its sedative effect, bed sharing with the infant is not recommended if this drug is being taken. (UNICEF 2018, 2017, 2017, 2014, 2014, 2013 and 2006, Landa 2012, ABM 2008)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Brompheniramine Maleate is also known as


Brompheniramine Maleate in other languages or writings:

Group

Brompheniramine Maleate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Brompheniramine Maleate in its composition:

  • Alahist IR
  • Allent™. Contains other elements than Brompheniramine Maleate in its composition
  • Bomine
  • Brofed™. Contains other elements than Brompheniramine Maleate in its composition
  • Bromma
  • Bromphen
  • Bromsin
  • Brotapp™. Contains other elements than Brompheniramine Maleate in its composition
  • Capsiflu Total™. Contains other elements than Brompheniramine Maleate in its composition
  • Ciprofen™. Contains other elements than Brompheniramine Maleate in its composition
  • Cripofen™. Contains other elements than Brompheniramine Maleate in its composition
  • Decongex Plus™. Contains other elements than Brompheniramine Maleate in its composition
  • Dimegan (France)
  • Dimetane
  • Dimetapp™. Contains other elements than Brompheniramine Maleate in its composition
  • Dimetapp Expectorante (Brazil)™. Contains other elements than Brompheniramine Maleate in its composition
  • Dimotane
  • Disobrom™. Contains other elements than Brompheniramine Maleate in its composition
  • Disofrol™. Contains other elements than Brompheniramine Maleate in its composition
  • Disophrol™. Contains other elements than Brompheniramine Maleate in its composition
  • Dristan Allergy™. Contains other elements than Brompheniramine Maleate in its composition
  • Drixoral (United States of America, Indonesia)™. Contains other elements than Brompheniramine Maleate in its composition
  • Drixoral™. Contains other elements than Brompheniramine Maleate in its composition
  • Ilvico™. Contains other elements than Brompheniramine Maleate in its composition
  • J-COF DHC™. Contains other elements than Brompheniramine Maleate in its composition
  • J-Tan
  • Oraminic II
  • Poly-Tussin DHC™. Contains other elements than Brompheniramine Maleate in its composition
  • Probrom
  • Sedalmerck Flu™. Contains other elements than Brompheniramine Maleate in its composition
  • Sinadrin PE™. Contains other elements than Brompheniramine Maleate in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 435 daltons
VD 11.7 l/Kg
pKa 3.9 -
Tmax 3 hours
25 hours

References

  1. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  2. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  3. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  4. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  5. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  6. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  8. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  9. Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. Review. Abstract
  10. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977 Abstract

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