Last update March 22, 2015

Brivudine

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Medication used for treatment of Herpes zoster infection.

At latest update, relevant published data on excretion into breast milk were not found.

Because a high distribution volume (DV) and high protein-binding capacity, excretion into breast milk in significant amount is very unlikely.

A low oral bioavailability impairs the pass of it from the mother's milk to the infant's plasma, except in prematures or in the early neonatal period, when a higher intestinal absorption may occur.

Until more data on this medication is available, safer alternative drugs are preferred, especially in such critical age periods.

Alternatives

  • Acyclovir ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Valaciclovir ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Brivudine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Brivudine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 %
Molecular weight 333 daltons
Protein Binding > 95 %
VD 1 l/Kg
Tmax 1 hours
T1/2 16 hours

References

  1. McDonald EM, de Kock J, Ram FS. Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials. Antivir Ther. 2012 Abstract
  2. AEMPS. Brivudina. Ficha técnica. 2010 Full text (in our servers)
  3. Wassilew S; Collaborative Brivudin PHN Study Group. Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study. J Eur Acad Dermatol Venereol. 2005 Abstract
  4. Keam SJ, Chapman TM, Figgitt DP. Brivudin (bromovinyl deoxyuridine). Drugs. 2004 Abstract
  5. Rabasseda X. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 Abstract

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