Last update June 14, 2022
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Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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باليبيريدون is Paliperidone in Arabic.
Is written in other languages:باليبيريدون is also known as
باليبيريدون belongs to these groups or families:
Main tradenames from several countries containing باليبيريدون in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 28 | % |
Molecular weight | 427 | daltons |
Protein Binding | 74 | % |
VD | 7 | l/Kg |
pKa | 13.74 | - |
Tmax | 24; Depot: 312 | hours |
T½ | 23; Depot: 312 | hours |
Relative Dose | 1 - 4.7 | % |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Atypical or second-generation antipsychotic indicated for the treatment of schizophrenia. It is the active metabolite of Risperidone. Oral (or intramuscular) administration once daily.
Risperidone and its active metabolite (paliperidone) are excreted in breastmilk in very small amounts.(Weggelaar 2011, Aichhorn 2005, Ilett 2004, Hill 2000).
No problems have been observed in infants whose mothers were taking Risperidone. (Viguera 2022, Aichhorn 2005, Ilett 2004, Ratnayake 2002)
The paliperiden plasma levels of these infants were undetectable or very low. (Aichhorn 2005, Ilett 2004)
May be a cause of hyperprolactinemia and galactorrhea. (Zhu 2021, Ray 2020, Skopek 2010)
Expert authors consider this medication possible with caution during breastfeeding. (Hale, Uguz 2021), although other alternatives, such as olanzapine or quetiapine, may be preferable. (Hale, LactMed, Klinger 2013)
Thera are two types of Paliperidone: oral and intramuscular (Depo). Depo type (Paliperidone Palmitate) requires intramuscular administration with a TMax (Time to peak plasma level) of 13 days and a T1/2 (Elimination half-life) of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.
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