Last update May 3, 2022

Bismuth salts (not salicylate)

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Bismuth salts (aluminate, citrate, subcitrate, subcarbonate, subnitrate) are used alone or together with other components in preparations against gastritis and diarrhea. Oral administration.

At latest update no published data on excretion into breast milk were found.

A very small amount of bismuth is absorbed from the gut: ≈ 0.1% (Tora 2020, Chen 2010, Boertz 2009, Dresow 1992). Bismuth is not absorbed into the systemic circulation of the mother, so it cannot be excreted in breast milk.

 


See below the information of this related product:

  • Bismuth Salicylate (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Alternatives

We do not have alternatives for Bismuth salts (not salicylate) since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Bismuth salts (not salicylate) in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 0.2 %
Molecular weight 394 - 1.462 daltons
Protein Binding > 90 %
120 - 250 hours

References

  1. Tora. Subcitrato de bismuto (Gastrodenol). Ficha técnica. 2020 Full text (in our servers)
  2. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  3. Boertz J, Hartmann LM, Sulkowski M, Hippler J, Mosel F, Diaz-Bone RA, Michalke K, Rettenmeier AW, Hirner AV. Determination of trimethylbismuth in the human body after ingestion of colloidal bismuth subcitrate. Drug Metab Dispos. 2009 Feb;37(2):352-8. Abstract
  4. Dresow B, Fischer R, Gabbe EE, Wendel J, Heinrich HC. Bismuth absorption from 205Bi-labelled pharmaceutical bismuth compounds used in the treatment of peptic ulcer disease. Scand J Gastroenterol. 1992 Apr;27(4):333-6. Abstract

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