Last update Sept. 4, 2022

Βηταϊστίνη

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a histamine analog used in the treatment of Ménière's vertigo without sufficient evidence of its efficacy (Strupp 2020, Rosenbaum 2017, Murdin 2016, Della 2006, James 2001). Oral administration.

At latest update, relevant information on excretion into breast milk was not found.

Because of pharmacokinetic data it is likely excretion into breast milk, but though from very low plasma levels, usually below the detection threshold (100 pg/mL), so it is unlikely that the amount that could reach breast milk is significant.

Potential side effects (nausea, dyspepsia, and headache) are mild and well tolerated. (Murdin 2016)

Consider other better known options, otherwise follow-up the child for symptoms like nausea, crying and fussiness. Waiting to breastfeed for 3 to 4 hours after taking betahistine minimizes passage into milk.

Alternatives

  • Diazepam (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Dimenhydrinate (Safe substance and/or breastfeeding is the best option.)
  • Diphenhydramine (Safe substance and/or breastfeeding is the best option.)
  • Domperidone (Safe substance and/or breastfeeding is the best option.)
  • Meclozine Hydrochloride (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Oxcarbazepine (Safe substance and/or breastfeeding is the best option.)
  • Promethazine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Βηταϊστίνη is Betahistine in Greek.

Is written in other languages:

Βηταϊστίνη is also known as

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 136 daltons
Protein Binding < 5% %
Tmax 1 hours
3.5 hours

References

  1. Strupp M, Dlugaiczyk J, Ertl-Wagner BB, Rujescu D, Westhofen M, Dieterich M. Vestibular Disorders. Dtsch Arztebl Int. 2020 Apr 24;117(17):300-310. Abstract
  2. Rosenbaum A, Winter M. Is betahistine effective for Ménière’s disease? Medwave. 2017 Oct 31;17(8):e7068. Abstract
  3. Murdin L, Hussain K, Schilder AG. Betahistine for symptoms of vertigo. Cochrane Database Syst Rev. 2016 Jun 21;(6):CD010696. Abstract
  4. Monzani D, Barillari MR, Alicandri Ciufelli M, Aggazzotti Cavazza E, Neri V, Presutti L, Genovese E. Effect of a fixed combination of nimodipine and betahistine versus betahistine as monotherapy in the long-term treatment of Ménière's disease: a 10-year experience. Acta Otorhinolaryngol Ital. 2012 Abstract Full text (link to original source) Full text (in our servers)
  5. Betahistina. Ficha técnica. 2011 Full text (in our servers)
  6. Betahistine. Drug Summary. 2010 Full text (in our servers)
  7. Della Pepa C, Guidetti G, Eandi M. Betahistine in the treatment of vertiginous syndromes: a meta-analysis. Acta Otorhinolaryngol Ital. 2006 Abstract Full text (link to original source) Full text (in our servers)
  8. James AL, Burton MJ. Betahistine for Menière's disease or syndrome. Cochrane Database Syst Rev. (rev. 2011) 2001 Abstract Full text (link to original source) Full text (in our servers)

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