Last update June 15, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Азенапина Малеат is Asenapine Maleate in Cyrillic.
Is written in other languages:Азенапина Малеат belongs to these groups or families:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | subling: 35; oral: <2% | % |
Molecular weight | 402 | daltons |
Protein Binding | 95 | % |
VD | 20 - 25 | l/Kg |
Tmax | 0.5 - 1.5 | hours |
T½ | 24 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Atypical or second generation antipsychotic used in the treatment of schizophrenia and bipolar disorder. Sublingual administration twice daily.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (very high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.
Its practically zero oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.
Clozapine has little or no significant effect on prolactin levels. (Peuskens 2014, Citrome 2014)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Klinger 2013), especially during the neonatal period and in the event of prematurity.
See below the information of this related product: