Last update June 30, 2015

Azelastine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Second generation anti-histaminic drug with low sedative effect. Used for ophthalmic and nasal topical administration.

On last update no relevant published data related to breastfeeding were found.

A small dose together with a low plama level of most nasal and ophthalmologic compounds make that a significant excretion into breast milk would be unlikely.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Azelastine in other languages or writings:

Groups

Azelastine belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 418 daltons
Protein Binding 80 - 90 %
VD 15 l/Kg
Tmax 2 - 5 hours
T½ 22 - 35 hours

References

  1. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract

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