Last update April 16, 2024

Ацетазоламид

Compatible

Safe product and/or breastfeeding is the best option.

Carbonic anhydrase inhibitor diuretic used in the treatment of glaucoma and also intracranial hypertension and in certain epilepsies. Oral administration one to four times a day.

It is excreted in breast milk in a clinically insignificant amount and no problems have been observed in infants whose mothers took it in doses up to 1,500 mg (1.5 g) daily. (Ibrahim 2019, Söderman 1984).

The plasma levels of these infants were very low. (Söderman 1984)

Various expert authors consider the use of this medication safe during breastfeeding (Hale, LactMed, Bumen 2020, Belkin 2020, Briggs 2015, Schaefer 2015, Chen 2010). American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001). WHO list of essential medicines: compatible with breastfeeding. (WHO/UNICEF 2002)

Alternatives

We do not have alternatives for Ацетазоламид since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Ацетазоламид is Acetazolamide in Cyrillic.

Is written in other languages:

Ацетазоламид is also known as

Groups

Ацетазоламид belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Ацетазоламид in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 222 daltons
Protein Binding 98 %
VD 0.2 l/Kg
pKa 7.2 -
Tmax 2 - 3 hours
T½ 3 - 9 hours
M/P ratio 0.3 -
Theoretical Dose 0.3 mg/Kg/d
Relative Dose 1.8 %
Ped.Relat.Dose 1 - 3 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  4. Blumen-Ohana E, Sellem E. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  5. Ibrahim A, Hussain N. Brief report: Metabolic acidosis in newborn infants following maternal use of acetazolamide during pregnancy. J Neonatal Perinatal Med. 2019 Nov 16. Abstract
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  7. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  8. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  9. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  11. Söderman P, Hartvig P, Fagerlund C. Acetazolamide excretion into human breast milk. Br J Clin Pharmacol. 1984 Abstract

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