Last update April 12, 2021

Atovaquone

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Drug used for treatment and prophylaxis of Pneumoystis pneumonia. Also used in combination with Proguanil for treatment of malaria.
Oral administration.

On latest update relevant data on breastfeeding was not found (Saito 2018).

Pharmacokinetic data indicates that drug excretion into breast milk would not be significant.

It has been approved to treat infants over 5 kg of body weight (CDC 2019, Chen 2010, Prescrire 2009, Borrmann 2003). May be used in nursing mothers of newborn and babies under 5 kg of body weight since benefit is greater than risk (CDC 2019).


See below the information of this related product:

  • Proguanil (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Chloroquine (Safe product and/or breastfeeding is the best option.)
  • Mefloquine Hydrochloride (Safe product and/or breastfeeding is the best option.)
  • Quinine (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Atovaquone in other languages or writings:

Group

Atovaquone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Atovaquone in its composition:

List of 9 tradenames
  • Malanil™. Contains other elements than Atovaquone in its composition
  • Malarone™. Contains other elements than Atovaquone in its composition
  • Malaway™. Contains other elements than Atovaquone in its composition
  • Maloff Protect™. Contains other elements than Atovaquone in its composition
  • Mepron™
  • Promal™. Contains other elements than Atovaquone in its composition
  • Promozio™. Contains other elements than Atovaquone in its composition
  • Provaquoneg™. Contains other elements than Atovaquone in its composition
  • Wellvone™

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 23 - 47 %
Molecular weight 367 daltons
Protein Binding 100 %
VD 0.60 ± 0.17 l/Kg
pKa 5.5 -
T½ 48 - 72 hours

References

  1. AEMPS. Malarone (Atovacuona + Proguanil). Ficha técnica. 2020 Full text (in our servers)
  2. CDC. Centers for Disease Control and Prevention. Tan K, Arguin PM. Chapter 4. Travel-Related Infectious Diseases. Malaria. CDC Health Information for International Travel. 2019 Full text (link to original source)
  3. Saito M, Gilder ME, McGready R, Nosten F. Antimalarial drugs for treating and preventing malaria in pregnant and lactating women. Expert Opin Drug Saf. 2018 Nov;17(11):1129-1144. Abstract Full text (link to original source) Full text (in our servers)
  4. GSK. Malarone (Atovaquone + Proguanil). Drug Summary. 2015 Full text (in our servers)
  5. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (in our servers)
  6. [No authors listed] Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children. Prescrire Int. 2009 Abstract
  7. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  8. Borrmann S, Faucher JF, Bagaphou T, Missinou MA, Binder RK, Pabisch S, Rezbach P, Matsiegui PB, Lell B, Miller G, Kremsner PG. Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children. Clin Infect Dis. 2003 Abstract Full text (link to original source) Full text (in our servers)

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