Aspirin (anlgesic, antipyretic, > 300 mg/day)

Nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic properties. Usually administered orally, every 4-6 hours starting at 500 mg per day to relieve pain or fever.

ANALGESIC-ANTIPYRETIC USE, MEDIUM-HIGH DOSES, > 300 mg/day

Excreted in small amounts in breast milk ^{(Datta 2017, Athavale 2013, Bailey 1982, Findlay 1981, Erickson 1979)}, but negligible when maternal doses of aspirin are less than 500 mg. ^{(Datta 2017).}

Although low plasma levels have been detected in infants ^{(Unsworth 1987)}, no cases of Reye's syndrome due to aspirin in breast milk have been reported, and it is considered very unlikely to occur with isolated doses. ^{(Shepherd 2020)}

Various medical societies, experts, and expert consensus groups consider the occasional isolated use or antiplatelet doses of aspirin during breastfeeding to be safe or probably safe. ^{(Datta 2017, Noviani 2016, Rowe 2013, Sachs 2013, Bell 2011, Chen 2010, Bar -Oz 2003, WHO 2002, Spigset 2000)}

With maternal doses in the usual therapeutic analgesic-antipyretic-anti-inflammatory range, there are three older publications on side effects in infants: a highly dubious case of salicylic poisoning in the neonatal period (Clark 1981), thrombocytopenia in an infant ^{(Terragna 1967)}, and a hemolytic crisis in a 23-day-old newborn with glucose-6-phosphate dehydrogenase deficiency. ^{(Harley 1962)}

Other studies have found no problems in infants whose mothers took aspirin. ^{(Ito 1993)}

For use in usual doses as an anti-inflammatory, analgesic, or antipyretic, safer alternatives are preferred during breastfeeding. ^{(Noviani 2016, Davanzo 2014, Bloor 2013, Sachs 2013, Worthington 2013, Risser 2009, WHO 2002, Janssen 2000)}

See below the information of this related product:

• Aspirin (antiplatelet, ≤ 300 mg/day) (Safe product and/or breastfeeding is the best option.)