Last update March 30, 2023
Incompatible
We do not have alternatives for As2 O3 .
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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As2 O3 is Arsenic Trioxide in Molecular formula.
Is written in other languages:As2 O3 is also known as
As2 O3 belongs to these groups or families:
Main tradenames from several countries containing As2 O3 in its composition:
Variable | Value | Unit |
---|---|---|
Molecular weight | 197 | daltons |
Protein Binding | 75 | % |
VD | 5.7 | l/Kg |
Tmax | 5 | hours |
T½ | 14; DMA: 70 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Inorganic form of arsenic used for the treatment of acute promyelocytic leukemia. Intravenous administration. A daily dose until remission or a maximum of 50-60 days and then 5 weekly doses for 4 to 5 weeks, several cycles separated by 4 weeks of rest. (EMA 2018)
Since the last update, we have not found published data on its excretion in breastmilk.
During cancer treatment, breastfeeding must be interrupted due to potentially serious side effects for the infant.
It is known from pharmacokinetics that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ 94% is eliminated, after 5 T½ 96.9%, after 6 T½ 98.4% and after 7 T½ 99%. From 7 T½ the plasma concentrations of the drug in the body are negligible. In general, a period of at least five half-lives can be considered a safe waiting period before breastfeeding again.(Anderson 2016)
Although expert authors report waiting times before breastfeeding of 1 week after the last dose (LactMed 2018), taking into account the long half-life of the DMA metabolite (70 hours), it seems more prudent, as indicated by the manufacturer (Teva 2018), to wait 15 days (5 T½ of the metabolite DMA and 25 T½ of the parent compound) after the last dose to restart breastfeeding. Meanwhile, express and discard breast milk regularly in order to maintain production.
When it is possible to do so, the milk detections of each patient to determine the total elimination of the drug are the best indicator to be able to resume breastfeeding between two cycles of chemotherapy.
Continued and long treatment cycles make it very difficult to continue with breastfeeding.
Some chemotherapeutic agents with an antibiotic effect can alter the composition of the microbiota (bacterial set or bacterial flora) of the milk and the concentration of some of its components (Urbaniak 2014). This possibly occurs temporarily with subsequent recovery, although no harmful effects are assumed or reported in breastfed infants.
Women undergoing chemotherapy during pregnancy have lower rates of breastfeeding due to difficulties in breastfeeding (Stopenski 2017), needing more support to achieve it.
Given the strong evidence that exists on the benefits of breastfeeding for the development of babies and the health of mothers, it is advisable to evaluate the risk-benefit of any maternal treatment, including chemotherapy, individually advising each mother that wishes to continue with breastfeeding.(Koren 2013)
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