Last update Dec. 22, 2013

Anagrelide-Hydrochloride

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

On latest update relevant data on breastfeeding were not found.

Since it is usually prescribed for long-term treatment and it does not have a low oral bioavailability, infant coagulation could be affected.

Potential adverse effects would be minimized by delaying nursing for 4-5 hours after last dose and checking-up for infant platelet count.

Alternatives

  • Hydroxycarbamide (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Interferon alfa ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Anagrelide-Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Anagrelide-Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 %
Molecular weight 311 daltons
Tmax 1 hours
T1/2 1,3 hours

References

  1. Ramirez G, García-Sanchez R, Plaza S. [Management of patients with essential thrombocythemia]. Med Clin (Barc). 2013 Abstract
  2. EMEA Anagrelida Ficha técnica 2009 Full text (in our servers)
  3. EMEA Anagrelide Data Sheet 2009 Full text (in our servers)

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