Last update Jan. 5, 2023

Amyl Nitrite

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Amyl nitrite is a fast-acting vasodilator used by inhalation to treat cyanide poisoning. It has also been used as an antihypertensive and to treat angina pectoris. As a drug of abuse it has a psychoactive effect. It is used as a cleaning agent and as an industrial and household solvent.

At the date of the last update we did not find any published data on its excretion in breast milk.

It can cause methemoglobinemia and contact dermatitis. (Elgendy 2022, Kluger 2021)

Rapid and short-acting drug (minutes). In case of a breastfeeding mother who would have taken this drug, it would be necessary for her to wait for few hours before resumption of suckling.

See below the information of this related product:

  • Nitrate / Nitrite (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)


We do not have alternatives for Amyl Nitrite.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amyl Nitrite is also known as

Amyl Nitrite in other languages or writings:


Main tradenames from several countries containing Amyl Nitrite in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 117 daltons
Protein Binding 60 %
Tmax 0.03 - 0.3 hours
0.02 - 0.07 hours


  1. Elgendy F, Rio-Pertuz GD, Nguyen D, Payne D. "Popper" induced methemoglobinemia. Proc (Bayl Univ Med Cent). 2022 Feb 2;35(3):385-386. Abstract Full text (link to original source)
  2. Kluger N, Frances P. Unilateral contact dermatitis of the breast caused by amyl nitrites (poppers). Ann Dermatol Venereol. 2021 Jun;148(2):139. Abstract

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