Last update May 4, 2022

Ampicillin - Sulbactam

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Sulbactam is a penicillanic acid sulfone with beta-lactamase inhibitory properties. It is given with ampicillin in the treatment of infections in which beta-lactamase production is suspected. Oral and parenteral administration every 4 to 6 hours.

Both ampicillin and sulbactam are excreted in breast milk in insignificant amounts (Campbell AC 1991, Matheson I 1988, Nau H 1987, Foulds G 1985, Matsuda S 1985) and no side effects have been observed in infants whose mothers were taking it. (Rowe 2013, AAP 2001)

Follow-up for appearance of diarrhea since alteration of intestinal flora can occur (Chin KG 2000). The possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Benyamini 2005, Ito 1993, Kafetzis 1981)

Alternatives

We do not have alternatives for Ampicillin - Sulbactam since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ampicillin - Sulbactam is also known as


Ampicillin - Sulbactam in other languages or writings:

Group

Ampicillin - Sulbactam belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ampicillin - Sulbactam in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 349/255 daltons
Protein Binding 8 - 28 %
Tmax 1 -2 hours
1.5 hours
M/P ratio 0.6 -
Theoretical Dose 0.2 mg/Kg/d
Relative Dose 1.2 %
Ped.Relat.Dose 0.1 %

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Benyamini L, Merlob P, Stahl B, Braunstein R, Bortnik O, Bulkowstein M, Zimmerman D, Berkovitch M. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit. 2005 Abstract
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Chin KG, Mactal-Haaf C, McPherson CE. Use of anti-infective agents during lactation: Part 1--Beta-lactam antibiotics, vancomycin, quinupristin-dalfopristin, and linezolid. J Hum Lact. 2000 Abstract
  5. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  6. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  7. [No authors listed] Proceedings of the British Pharmacological Society. 12-14 September 1990, Belfast. Br J Clin Pharmacol. 1991 Abstract
  8. Campbell AC, McElnay JC, Passmore CM. The excretion of ampicillin in breast milk and its effect on the suckling infant. Br J Clin Pharmacol;31:230p. Abstract. 1991 Full text (link to original source) Full text (in our servers)
  9. Matheson I, Samseth M, Sande HA. Ampicillin in breast milk during puerperal infections. Eur J Clin Pharmacol. 1988;34(6):657-9. Abstract
  10. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  11. Matsuda S, Kashiwagura T, Hirayama H. [Passage into the human milk and clinical evaluation of sulbactam/cefoperazone]. Jpn J Antibiot. 1985 Abstract
  12. Foulds G, Miller RD, Knirsch AK, Thrupp LD. Sulbactam kinetics and excretion into breast milk in postpartum women. Clin Pharmacol Ther. 1985 Abstract
  13. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

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