Last update Aug. 12, 2014

Amiloride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Potassium-sparing diuretic.

On latest update relevant data on breastfeeding were not found.

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting and loop-acting effect) may inhibit lactation. Use the lower dose as possible especially during the first postnatal month.

Alternatives

  • Spironolactone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Group

Amiloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amiloride in its composition:

List of 15 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 %
Molecular weight 302 daltons
Protein Binding < 10 %
Tmax 3 - 4 hours
T½ 6 - 9 hours

References

  1. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  2. Vidt DG. Mechanism of action, pharmacokinetics, adverse effects, and therapeutic uses of amiloride hydrochloride, a new potassium-sparing diuretic. Pharmacotherapy. 1981 Abstract

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