Last update Jan. 19, 2023

Amiloride Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a weak, potassium-sparing diuretic that is used as an adjunct to thiazide diuretics such as hydrochlorothiazide and loop diuretics such as furosemide to conserve potassium.
It is used in the treatment of edema associated with liver cirrhosis and heart failure and in the treatment of hypertension. Oral administration once a day.

On latest update relevant data on breastfeeding were not found.

Long-term treatment with diuretic drugs may compromise the state of hydration of the nursing mother. Must make an adjustment (decrease) of the dose based on the estimated milk production and monitor milk production. Use a lower dose as possible, especially during the first postnatal month.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (WHO 2002), especially during the neonatal period and in the event of prematurity.

Alternatives

  • Chlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hydrochlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Spironolactone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amiloride Hydrochloride is also known as


Amiloride Hydrochloride in other languages or writings:

Group

Amiloride Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amiloride Hydrochloride in its composition:

  • Ameride (Spain)™. Contains other elements than Amiloride Hydrochloride in its composition
  • Amiclaran
  • Amidal
  • Amikal
  • Amilamont
  • Amiloclor™. Contains other elements than Amiloride Hydrochloride in its composition
  • Amiloferm™. Contains other elements than Amiloride Hydrochloride in its composition
  • Amiretic™. Contains other elements than Amiloride Hydrochloride in its composition
  • Amizide™. Contains other elements than Amiloride Hydrochloride in its composition
  • Ancloric™. Contains other elements than Amiloride Hydrochloride in its composition
  • Comilorid™. Contains other elements than Amiloride Hydrochloride in its composition
  • Diupress™. Contains other elements than Amiloride Hydrochloride in its composition
  • Diurex A™. Contains other elements than Amiloride Hydrochloride in its composition
  • Diurisa™. Contains other elements than Amiloride Hydrochloride in its composition
  • Diuzine
  • Errolon A™. Contains other elements than Amiloride Hydrochloride in its composition
  • Frumil™. Contains other elements than Amiloride Hydrochloride in its composition
  • Furdiuren™. Contains other elements than Amiloride Hydrochloride in its composition
  • Hidrenox A™. Contains other elements than Amiloride Hydrochloride in its composition
  • Hidrium™. Contains other elements than Amiloride Hydrochloride in its composition
  • Kalten
  • Kaluril
  • Logirène™. Contains other elements than Amiloride Hydrochloride in its composition
  • Medamor
  • Midamor
  • Miramor
  • Modamide
  • Moducren™. Contains other elements than Amiloride Hydrochloride in its composition
  • Moduret™. Contains other elements than Amiloride Hydrochloride in its composition
  • Moduretic™. Contains other elements than Amiloride Hydrochloride in its composition
  • Nirulid
  • Normorix™. Contains other elements than Amiloride Hydrochloride in its composition
  • Nuriban A™. Contains other elements than Amiloride Hydrochloride in its composition
  • Plenacor D (Argentina)™. Contains other elements than Amiloride Hydrochloride in its composition
  • Ren-Ur™. Contains other elements than Amiloride Hydrochloride in its composition
  • Sparkal™. Contains other elements than Amiloride Hydrochloride in its composition
  • Tensoflux™. Contains other elements than Amiloride Hydrochloride in its composition
  • Tiaden™. Contains other elements than Amiloride Hydrochloride in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 %
Molecular weight 302 daltons
Protein Binding 40 %
VD 5 l/Kg
pKa 11.43 -
Tmax 3 - 4 hours
9.6 ± 1.8 hours

References

  1. Sun Q, Sever P. Amiloride: A review. J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320975893. Abstract Full text (link to original source)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. Vidt DG. Mechanism of action, pharmacokinetics, adverse effects, and therapeutic uses of amiloride hydrochloride, a new potassium-sparing diuretic. Pharmacotherapy. 1981 Abstract

Total visits

7,424

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM