Last update March 29, 2023

Amidotrizoate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

The X-ray contrast media that contain Amidotryzoic acid or its compounds diatrizoate and meglumine or sodium amidotrizoatehave a content of Iodine from 47% to 62%. Intravenous administration.

Amidotryzoate excretion into breast milk is nil (Fitzjohn 1982) or in clinically non-significant amount,  < 0.1% of maternal dose. (Texier 1983, Weyrauch 1977)

Several medical societies and expert authors consider the use of this medication to be safe or very probably safe during breastfeeding (Hale, Briggs 2015). American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001). Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other and one of them is their data no or minimal excretion in milk.

Given the low lipid solubility of the iodinated contrast, less than 1% of the dose administered to the mother just passing milk. Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that he may take the infant. The maximum dose just getting the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to a nursing practice that is a radiological contrast examination.

Most experts and radiology scientific societies agree that after a radiological iodinated contrast examination is not necessary to wait no time to nurse.

 


See below the information of this related product:

Alternatives

We do not have alternatives for Amidotrizoate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amidotrizoate is also known as


Amidotrizoate in other languages or writings:

Group

Amidotrizoate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amidotrizoate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1% %
Molecular weight 636 - 809 daltons
Protein Binding 9 %
Tmax 0.1 hours
0.5 - 2 hours
M/P ratio 0.1 -
Relative Dose 0.03 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Texier F, Roque d'Orbcastel O, Etling N. [Stable iodine level in human milk after pulmonary angiography]. Presse Med. 1983 Mar 19;12(12):769. French. No abstract available. Abstract
  6. FitzJohn TP, Williams DG, Laker MF, Owen JP. Intravenous urography during lactation. Br J Radiol. 1982 Aug;55(656):603-5. No abstract available. Abstract
  7. Weyrauch U, Volkhardt V, Speck U. Úübergang von Amidotrizoat in die Mutermilch nach Phiebographie bei einer Patientin 10 Tage post partum. [Transfer of amidotrizoate in maternal milk following phlebography in a patient 10 days post partum]. Rofo. 1977 Sep;127(3):275-6. German. No abstract available. Abstract

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