Last update Feb. 1, 2017
Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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Thank you for helping to protect and promote breastfeeding.
Amantadine Hydrochloride is also known as
Amantadine Hydrochloride in other languages or writings:
Amantadine Hydrochloride belongs to these groups or families:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 86 - 90 | % |
Molecular weight | 188 | daltons |
Protein Binding | 67 | % |
VD | 4.2 | l/Kg |
Tmax | 2 - 4 | hours |
T½ | 10 - 15 | hours |
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e-lactancia is a resource recommended by IHAN of Spain
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Antiviral used for treatment and prophylaxis of type-A Influenza. Since it is a dopamine agonist is also used to treat Parkinson’s disease.
At latest update relevant published data on excretion into breast milk were not found.
Because of large volume of distribution and low plasma level observed (Pacifici 1976), a passage of significant amount through breastmilk or side-effects on the infant are not likely to occur.
Amantadine reduces plasma levels of prolactin, it has been used to treat galactorrhea caused by the use of dopaminergic neuroleptic drugs (Siever 1981 Correa 1987, Marken 1992, Carvalho 2011), however there is not information about the effect on lactating mothers. Prolactin is important to milk production especially during the first few weeks within birth. Frequent and effective stimulation of the nipple by the infant is essential on the maintenance of breastfeeding.
Whether administered during breastfeeding, it would be advisable not to use it in the neonatal period and monitor milk production.