Last update Feb. 27, 2023


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Allopurinol and its metabolite oxypurinol decrease the level of uric acid in plasma and urine by inhibiting the xanthine oxidase enzyme. Indicated for the treatment of clinical manifestations of uric acid/urate deposits, such as gout or gouty lithiasis. It has been used in Chagas disease. Oral administration.

In a mother, allopurinol was excreted in breast milk in an insignificant amount, but the levels of allopurinol were elevated. (Kamilli 1993 y 1991)

No clinical or laboratory problems were observed in two infants whose mothers was taking allopurinol (Thornley 1994, Kamilli 1993). The levels of allopurinol in the plasma of one infant were undetectable, but those of oxipurinol were almost at a therapeutic level. (Kamilli 1993 y 1991)

Allopurinol side effects are very rare and not serious. It can cause the appearance of rash. (AEMPS 2020, AA Pharma 2010)

American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001). Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)


  • Probenecid ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Allopurinol in other languages or writings:


Allopurinol belongs to this group or family:


Main tradenames from several countries containing Allopurinol in its composition:


Variable Value Unit
Oral Bioavail. 67 - 90 %
Molecular weight 136 daltons
Protein Binding 0 %
VD 1.6 l/Kg
pKa 8.47 -
Tmax 1.5 (oxipurinol: 4) hours
1 - 2 (oxipurinol: 15) hours
M/P ratio 0.9-1.4; oxipurinol: 2.4-3.9 -
Theoretical Dose 0.2 (+ 8 oxipurinol) mg/Kg/d
Relative Dose 4 (oxipurinol: 80) %
Ped.Relat.Dose 2 (Oxipurinol: 40-80) %


  1. AEMPS. Alopurinol. Ficha técnica. 2020 Full text (in our servers)
  2. AA Phama. Allopurinol. Drug Summary. 2010 Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Thornley S, Manoharan A. Successful treatment of essential thrombocythemia with alpha interferon during pregnancy. Eur J Haematol. 1994 Jan;52(1):63-4. No abstract available. Abstract
  6. Kamilli I, Gresser U. Allopurinol and oxypurinol in human breast milk. Clin Investig. 1993 Abstract
  7. Kamilli I, Gresser U, Schaefer C, Zöllner N. Allopurinol in breast milk. Adv Exp Med Biol. 1991 Abstract

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