Last update June 29, 2020



Safe substance and/or breastfeeding is the best option.

Retinoid analogue with similar properties as Tretinoine.
Used in the topical treatment of acne.

Since the last update we have not found any published data on its excretion in breast milk.

It is practically not absorbed by skin (AEMPS 2019, Galderma 2018, Abkhavan 2003), hence it cannot achieve significant levels in the milk (Hale 2019, Briggs 2017, Leachman 2006).

The manufacturer (AEMPS 2019, Galderma 2018) consider the use of this medication to be safe during breastfeeding.

Avoid using it on the breast or cleanse it thoroughly before nursing.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Adapalene is also known as

Adapalene in other languages or writings:


Adapalene belongs to this group or family:


Main tradenames from several countries containing Adapalene in its composition:


Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 413 daltons
pKa 4 -
17 ± 10 hours


  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from Consulted on April 10, 2024 Full text (link to original source)
  2. AEMPS-Galderma. Adapaleno (Differine). Ficha técnica. 2019 Full text (in our servers)
  3. Galderma. Adapalene (Differin gel). Drug Summary. 2018 Full text (in our servers)
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  6. Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol. 2003 Abstract

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