Last update Feb. 5, 2022

Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate

Compatible

Safe substance and/or breastfeeding is the best option.

Vitamin K is an essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors and in the function of proteins, such as osteocalcin, important for bone development.

The daily needs during pregnancy and breastfeeding are 90 micrograms a day. Vitamin K is found in many foods in the form of phytomenadione and is also synthesized by intestinal bacteria in the form of menaquinone. (Booth 2012).

With a varied diet, vitamin K supplements are not required. (Ares 2015)

Human milk is low in vitamin K and at birth there are not enough intestinal bacteria to synthesize it. Newborns require a vitamin K supplement to prevent hemorrhagic disease of the newborn (Greer 2001): an intramuscular dose of 0.5 to 1 mg (500 to 1,000 micrograms) at birth or orally 2 mg at birth followed by weekly doses for the first 12 weeks. (Ng 2018, Ares 2015)

Vitamin K occurs naturally in human milk and colostrum in concentrations of 1 to 20 micrograms/L and increases with maternal administration of vitamin K to levels between 50 and 150 micrograms/L (Bolisetty 1998, Greer 1997), but this is still insufficient to prevent hemorrhagic disease of the newborn, which requires the administration of vitamin K, regardless of the dose of Vitamin K that the mother takes. (Sauberan 2019)

American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)

WHO List of Essential Medicines: compatible with breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate is also known as Vitamin K Substances. Here it is a list of alternative known names::


Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate in other languages or writings:

Group

Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Acetomenaphthone; Menadiol Diacetate; Vitamin K4 Diacetate in its composition:

List of 13 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 13 ± 9 %
Molecular weight 451 daltons
Protein Binding 90 %
VD 0.29 l/Kg
Tmax 4.7 ± 0.8 hours
T½ 2 hours
Theoretical Dose <0.0001 mg/Kg/d
Relative Dose 0.003 %
Ped.Relat.Dose 0.0003 %

References

  1. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother's milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021 Jan 4;16(1):1. Abstract Full text (link to original source)
  2. Sauberan JB. High-Dose Vitamins. Breastfeed Med. 2019 Apr 30. Abstract
  3. Ng E, Loewy AD. Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada. Can Fam Physician. 2018 Oct;64(10):736-739. Abstract
  4. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. Booth SL. Vitamin K: food composition and dietary intakes. Food Nutr Res. 2012;56. Abstract
  6. EFSA. European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals. Scientific Committee on Food. 2006 Full text (link to original source) Full text (in our servers)
  7. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  8. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  9. Greer FR. Do breastfed infants need supplemental vitamins? Pediatr Clin North Am. 2001 Abstract
  10. Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. Abstract Full text (link to original source)
  11. Bolisetty S, Gupta JM, Graham GG, Salonikas C, Naidoo D. Vitamin K in preterm breastmilk with maternal supplementation. Acta Paediatr. 1998 Sep;87(9):960-2. Abstract
  12. Greer FR, Marshall SP, Foley AL, Suttie JW. Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. Pediatrics. 1997 Jan;99(1):88-92. Abstract

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