Acetaminophen

Analgesic and antipyretic. Indicated in the treatment of pain and fever. It has a weak anti-inflammatory effect. Oral, intravenous and rectal administration, every 4, 6 or 8 hours.

It is excreted in very small quantities in breast milk. ^{(AEMPS 2017, GSK 2015, Notarianni 1987, Bitzén 1981, Findlay 1981, Berlin 1980, Hurden 1980)} The amount that the infant can receive through breast milk is much lower than the usual pediatric dose.^{(Lee 1993)} 

No problems have been observed in infants whose mothers were taking it,^{(AEMPS 2017, Ito 1993)} except for one case of mild dermatitis in an infant. ^{(Matheson 1985)} 

No association has been observed between maternal paracetamol use and neurodevelopmental disorders in infants (autism spectrum disorder, ASD, attention deficit/hyperactivity disorder,ADHD).

The urinary levels of infants have been undetectable. ^{(AEMPS 2017, Berlin 1980)} Other authors have measured insignificant levels in urine, but only paracetamol, not their metabolites as in adults.^{(Notarianni 1987)} 

The hepatotoxicity of paracetamol is lower in newborns and small infants due to hepatic immaturity: the low levels of specific cytochrome P-450 enzymes hinder the conversion of the drug into its toxic metabolites. ^{(Reece 2017, Sachs 2013)} 

Medication commonly used in Pediatrics, with authorized use in neonates, including premature infants.

American Academy of Pediatrics: medication usually compatible with breastfeeding. ^{(AAP 2001)}

List of essential medicines WHO: compatible with breastfeeding. ^{(WHO / UNICEF, 2002)} 

The manufacturer ^{(AEMPS 2017, GSK 2015)} and expert authors and medical associations consider it compatible with breastfeeding. ^{(Reece 2017, Davanzo 2014, Rowe 2013, Worthington 2013, Sachs 2013, Amir 2011, Zrour 2010, Chen 2010, Østensen 2007, Nice 2004, Bannwarth 2003, Bar-Oz 2003, Janssen 2000, Nice 2000, Spigset 2000, Mitchell 1999, Bodley 1997, Lee 1993, Bitzen 1981, Berlin 1980)}