Last update May 20, 2025

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide

Compatible

Safe product and/or breastfeeding is the best option.

Centrally acting cough suppressant with properties and uses similar to dextromethorphan. Oral or rectal administration in three daily doses. 

Its high protein binding rate (Karlsson 1990) explains the very low passage into milk observed. (Olsson 1986)

In addition, its low oral bioavailability (Dahlström 1982) makes it difficult to pass into infant plasma from ingested breast milk.

American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)

Alternatives

We do not have alternatives for (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide is Noscapine in Chemical name.

Is written in other languages:

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide is also known as

Group

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide belongs to this group or family:

Tradenames

Main tradenames from several countries containing (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition:

List of 24 tradenames
  • AB Antitusivo™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Bisolnex™
  • Bucogerm Tos™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Capval™
  • Congestex™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Dolsom Flu™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Dolsom Flu Forte™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Freshmel Tos™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Geniol Dia™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Geniol Noche™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Neumobron™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Nipaxon™
  • Nosca-Mereprine™
  • Noscaflex™
  • Tapsin Antigripal Polvo Dia™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tapsin Antigripal Polvo Noche™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tapsin Antigrippal Polvo Dia™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tapsin Antigrippal Polvo Noche™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tapsin Limonada Dia™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tapsin Limonada Noche™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tuscalman (Spain)™
  • Tuscalman (Austria, Switzerland)™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition
  • Tussanil N™
  • Tussisédal™. Contains other elements than (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]phthalide in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 %
Molecular weight 413 daltons
Protein Binding 93 %
VD 4.7 l/Kg
Tmax 2.5 hours
T½ 2.6 - 4.5 hours
M/P ratio 0.15 - 0.88 -
Theoretical Dose 0.002 - 0.01 mg/Kg/d
Relative Dose 0.07 - 0.8 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Karlsson MO, Dahlström B, Eckernäs SA, Johansson M, Alm AT. Pharmacokinetics of oral noscapine. Eur J Clin Pharmacol. 1990 Abstract
  3. Karlsson MO, Dahlström B. Serum protein binding of noscapine: influence of a reversible hydrolysis. J Pharm Pharmacol. 1990 Abstract
  4. Olsson B, Bolme P, Dahlström B, Marcus C. Excretion of noscapine in human breast milk. Eur J Clin Pharmacol. 1986 Abstract
  5. Dahlström B, Mellstrand T, Löfdahl CG, Johansson M. Pharmacokinetic properties of noscapine. Eur J Clin Pharmacol. 1982 Abstract

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