Last update: March 27, 2015

ζαλεπλόνη

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Used for treatment of insomnia.

It is excreted in non-significant clinical amount into breast milk.

Foods with high fat content may delay absorption by the gut. A low oral bioavailability decreases the pass of it from the mother's milk to the infant's plasma, except in prematures or in the early neonatal period, when a higher intestinal absorption may occur.

Not commercially available in Spain

Alternatives

We do not have alternatives for ζαλεπλόνη since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

ζαλεπλόνη is also known as Zaleplon. Here it is a list of alternative known names::


Group

ζαλεπλόνη belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 %
Molecular weight 305 daltons
Protein Binding 60 %
Tmax 1 hours
T1/2 1 hours
M/P ratio 0,5 -
Theoretical Dose 0,002 mg/Kg/d
Relative Dose 1,2 %
Relat.Ped.Dose 1,5 %

References

  1. FDA. Zaleplon. Drug Summary. 2005 Full text (in our servers)
  2. Drover DR. Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: zaleplon, zolpidem and zopiclone. Clin Pharmacokinet. 2004 Abstract
  3. WHO Expert Committee on Drug Dependence. Critical review of psychoactive substances. WHO Technical Report Series. Thirty-third Report 2003 Full text (link to original source) Full text (in our servers)
  4. OMS. Comité de Expertos de la OMS en Farmacodependencia. Examen crítico de psicofármacos. OMS. Serie de informes técnicos, 33 informe. 2003 Full text (in our servers)
  5. Osakidetza. Zaleplon. Ficha técnica. 2001 Full text (in our servers)
  6. Darwish M, Martin PT, Cevallos WH, Tse S, Wheeler S, Troy SM. Rapid disappearance of zaleplon from breast milk after oral administration to lactating women. J Clin Pharmacol. 1999 Abstract

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