Last update: Oct. 20, 2014

Ursodeoxycholic Acid

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Biliary salt that appears in low amount in the serum because it is absorbed to the portal circulation and completely excreted into biliary duct.

Excreted into breast milk in non-significant amount with no side-effects being observed among infants of treated mothers.

Medication that has been used for treatment of newborns and older infants.

Alternatives

We do not have alternatives for Ursodeoxycholic Acid since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 393 daltons
Protein Binding 96 - 99 %
Tmax 1 - 3 hours
Theoretical Dose < 0,03 mg/Kg/d
Relative Dose < 0,3 %

References

  1. Efe C, Kahramanoğlu-Aksoy E, Yılmaz B, Ozseker B, Takcı S, Roach EC, Purnak T, Kav T, Ozaslan E, Wahlin S. Pregnancy in women with primary biliary cirrhosis. Autoimmun Rev. 2014 Abstract
  2. Hjortø S, Skov L, Lykke JA. [Obstetric dermatoses.] Ugeskr Laeger. 2014 Abstract
  3. Vítek L, Zelenková M, Brůha R. Safe use of ursodeoxycholic acid in a breast-feeding patient with primary biliary cirrhosis. Dig Liver Dis. 2010 Abstract
  4. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  5. Goh SK, Gull SE, Alexander GJ. Pregnancy in primary biliary cirrhosis complicated by portal hypertension: report of a case and review of the literature. BJOG. 2001 Abstract Full text (link to original source) Full text (in our servers)
  6. Brites D, Rodrigues CM. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comemnts]. J Hepatol. 1998 Abstract
  7. Rudi J, Schönig T, Stremmel W. -Therapy with ursodeoxycholic acid in primary biliary cirrhosis in pregnancy-. Z Gastroenterol. 1996 Abstract
  8. Bachrach WH, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. part I. Dig Dis Sci. 1982 Abstract

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