Last update: May 1, 2016

Σιζαπρίδη μονοϋδρική

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

It is excreted into breast milk in clinically non-significant amount. No problems attributable to this drug have been observed among infants whose mothers were receiving this medication.

It may cause an increase of prolactin secretion.

American Academy of Pediatrics states that it is a medication usually compatible with breastfeeding.

Because of the high risk of QT-interval prolongation and cardiac arrhythmias in patients who are taking it, especially if other medicines are associated or patients are affected by other conditions, it has been withdrawn from the market in many countries.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Σιζαπρίδη μονοϋδρική is Cisapride in Greek.

Is written in other languages:

Group

Σιζαπρίδη μονοϋδρική belongs to this group or family:

Tradenames

Main tradenames from several countries containing Σιζαπρίδη μονοϋδρική in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 484 daltons
Protein Binding 98 %
Tmax 2 hours
T1/2 10 hours
M/P ratio 0,06 -
Theoretical Dose 0,0009 mg/Kg/d
Relative Dose 0,14 %
Relat.Ped.Dose 0,1 - 0,2 %

References

  1. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  2. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  3. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract
  4. Bennett JR. How safe and acceptable is cisapride? Scand J Gastroenterol Suppl. 1989 Abstract
  5. Hofmeyr GJ, Sonnendecker EW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986 Abstract

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