Last update: Sept. 4, 2014

Phenylpropanolamine

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

Appears as part of many compounds for cough relief, mucolytics, expectorants and nose decongestants. Single drug (one active principle only) medicines should be preferred mostly while breastfeeding.

On latest update relevant data on breastfeeding was not found.

Pharmacokinetic data indicates that drug excretion into breast milk may occur.

Withheld from marketing in many countries because of hypertension and severe side effects.

Alternatives

We do not have alternatives for Phenylpropanolamine.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Groups

Phenylpropanolamine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Phenylpropanolamine in its composition:

List of 27 tradenames
  • Actidue™
  • Actifed (India)™. Contains other elements than Phenylpropanolamine in its composition
  • Actiflu™. Contains other elements than Phenylpropanolamine in its composition
  • Afebrin™. Contains other elements than Phenylpropanolamine in its composition
  • Antiadipositum™
  • Basoplex™. Contains other elements than Phenylpropanolamine in its composition
  • Boxogetten S™
  • Calgayan™. Contains other elements than Phenylpropanolamine in its composition
  • Colcaps™
  • Contac™. Contains other elements than Phenylpropanolamine in its composition
  • Day & Night™. Contains other elements than Phenylpropanolamine in its composition
  • Dimetapp™. Contains other elements than Phenylpropanolamine in its composition
  • Dimetapp Expectorante (Brazil)™. Contains other elements than Phenylpropanolamine in its composition
  • Irritos™. Contains other elements than Phenylpropanolamine in its composition
  • Kontexin™
  • Lentostamin™. Contains other elements than Phenylpropanolamine in its composition
  • Nasomixin™
  • Neo-Diophen™. Contains other elements than Phenylpropanolamine in its composition
  • Numonyl Jarabe™. Contains other elements than Phenylpropanolamine in its composition
  • Ornade-2™
  • Rhinopront™. Contains other elements than Phenylpropanolamine in its composition
  • Rinexin™
  • Rinogan™. Contains other elements than Phenylpropanolamine in its composition
  • Rinomar (Finland, Sweden)™. Contains other elements than Phenylpropanolamine in its composition
  • Senioral™
  • Slim Caps™
  • Triaminic™

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 188 daltons
Protein Binding Low / Bajo %
VD 4,5 l/Kg
Tmax 0,5 - 2 hours
T1/2 3,8 - 4,3 hours

References

  1. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  2. Kanfer I, Dowse R, Vuma V. Pharmacokinetics of oral decongestants. Pharmacotherapy. 1993 Abstract
  3. Scherzinger SS, Dowse R, Kanfer I. Steady state pharmacokinetics and dose-proportionality of phenylpropanolamine in healthy subjects. J Clin Pharmacol. 1990 Abstract
  4. Kristiansson B, Abdul Ghani N, Eriksson M, Garle M, Qirbi A. Use of khat in lactating women: a pilot study on breast-milk secretion. J Ethnopharmacol. 1987 Abstract

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