Last update: June 30, 2015

Fosfomycin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Excretion into breast milk is not significant and no side effects on breastfed infants of treated mothers have been shown.

Approved for use as treatment on infants younger than a one year old.

A low oral bioavailability would protect the infant, except in the neonatal period or cases of prematurity. Calcium contained in the milk prevents it from absorption by the gut.

Be aware of the possibility of false negative results of bacterial cultures on febrile infants when the mother is on antibiotics.

Alternatives

We do not have alternatives for Fosfomycin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Fosfomycin in other languages or writings:

Group

Fosfomycin belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 - 40 %
Molecular weight 138 daltons
Protein Binding 1 %
VD 0,34 l/Kg
Tmax 1,5 - 3 hours
T1/2 4 - 6 hours
M/P ratio 0,1 -
Theoretical Dose 0,54 mg/Kg/d
Relative Dose 1 %
Relat.Ped.Dose 0,5 - 1 %

References

  1. PDR.net Fosfomycin Drug Summary 2014 Full text (in our servers)
  2. Gobernado M. [Fosfomycin]. Rev Esp Quimioter. 2003 Abstract Full text (link to original source) Full text (in our servers)
  3. AEMPS Fosfomicina Ficha técnica 2003 Full text (in our servers)
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  5. Bergan T, Thorsteinsson SB, Albini E. Pharmacokinetic profile of fosfomycin trometamol. Chemotherapy. 1993 Abstract
  6. Bergan T. Pharmacokinetic comparison between fosfomycin and other phosphonic acid derivatives. Chemotherapy. 1990 Abstract
  7. Bergan T. Degree of absorption, pharmacokinetics of fosfomycin trometamol and duration of urinary antibacterial activity. Infection. 1990 Abstract
  8. Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977 Abstract

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e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) from Mexico

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