Last update: July 14, 2015

Colistin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Pharmacokinetic data (high volume of distribution and molecular weight) would explain the minimal excretion into breast milk mentioned in two older reports.

Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.

Alternatives

We do not have alternatives for Colistin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Colistin is also known as


Groups

Colistin belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Colistin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 1750 daltons
Protein Binding 50 %
VD 190 l/Kg
Tmax 1 - 7 hours
T1/2 1,5 - 4 hours
M/P ratio 0,2 -
Theoretical Dose < 0,17 mg/Kg/d
Relative Dose < 3 %
Relat.Ped.Dose < 3 %

References

  1. LactMed. Colisitn. Full Record Display. 2015 Full text (in our servers)
  2. José de Jesús Coria Lorenzo, Alfredo Morayta Ramírez, Yetzamin Gutiérrez Muñoz. Polimixinas en la era de la multidrogorresistencia. Revista de Enfermedades Infecciosas en Pediatría 2011;25(98):66-70. 2011 Full text (in our servers)
  3. Luque S, Grau S, Berenguer N, Horcajada JP, Sorlí L, Montero MM, Salas E. [Shedding light on the use of colistin: still gaps to be filled]. Enferm Infecc Microbiol Clin. 2011 Abstract Full text (in our servers)
  4. Ratjen F, Rietschel E, Kasel D, Schwiertz R, Starke K, Beier H, van Koningsbruggen S, Grasemann H. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J Antimicrob Chemother. 2006 Abstract
  5. Li J, Coulthard K, Milne R, Nation RL, Conway S, Peckham D, Etherington C, Turnidge J. Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis. J Antimicrob Chemother. 2003 Abstract

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