Last update: July 2, 2015

Cloxacillin

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Like most penicillin-type antibiotics, excretion into breast milk is clinically non-significant. No harmful effects have been found among breastfed infants from treated mothers.

Widely used for treatment of Mastitis since it has an effective activity against Staphylococcus.

Be aware of false negative results of microbial cultures done from samples of febrile infants whose mothers are treated with antibiotics. Also, due to imbalance of intestinal flora a diarrheal disease can occur in the breastfed infant.

List of Essential Medicines by WHO 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Cloxacillin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cloxacillin in other languages or writings:

Group

Cloxacillin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cloxacillin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 - 60 %
Molecular weight 436 daltons
Protein Binding 95 %
VD 0,1 l/Kg
Tmax 1 - 2 hours
T1/2 3 hours
Theoretical Dose 0,03 - 0,06 mg/Kg/d
Relative Dose 0,1 - 0,4 %
Relat.Ped.Dose 0,06 - 0,1 %

References

  1. Amir LH. ABM Clinical Protocol #4: Mastitis, Revised March 2014. Breastfeed Med. 2014 Abstract Full text (link to original source) Full text (in our servers)
  2. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Abstract Full text (link to original source) Full text (in our servers)
  3. Spencer JP. Management of mastitis in breastfeeding women. Am Fam Physician. 2008 Abstract Full text (link to original source) Full text (in our servers)
  4. Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #4: mastitis. Revision, May 2008. Breastfeed Med. 2008 Abstract
  5. Nordeng H, Tufte E, Nylander G. [Treatment of mastitis in general practice]. Tidsskr Nor Laegeforen. 2003 Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. Bodley V, Powers D. Case management of a breastfeeding mother with persistent oversupply and recurrent breast infections. J Hum Lact. 2000 Abstract
  8. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  9. Ogle KS, Davis S. Mastitis in lactating women. J Fam Pract. 1988 Abstract
  10. Dixon JM. Repeated aspiration of breast abscesses in lactating women. BMJ. 1988 Abstract Full text (link to original source) Full text (in our servers)
  11. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  12. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract

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