Last update: Jan. 6, 2015

Atracurium

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because a relatively high molecular-weight and a high protein-binding capacity, excretion into breast milk is thought to be low.

In addition, it has a low oral bioavailability which means that absorption from the breast milk ingested may be low.

Atracurium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

Alternatives

We do not have alternatives for Atracurium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Atracurium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Atracurium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 1244 daltons
Protein Binding 82 %
VD 0,16 l/Kg
Tmax 0,1 hours
T1/2 0,3 hours

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014 Abstract
  2. Atracurio. Ficha técnica. 2011 Full text (in our servers)
  3. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)
  4. Atracurium. Drug Summary. 1996 Full text (in our servers)
  5. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994 Abstract
  6. Colin JN, Singlas E. [Metabolism and pharmacokinetics of atracurium]. Ann Fr Anesth Reanim. 1985 Abstract
  7. Ward S, Neill EA, Weatherley BC, Corall IM. Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose). Br J Anaesth. 1983 Abstract

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